Effective for the following conditions in children:
– nervousness
– anxiety
– distractibility
– impaired concentration
– inattention
– boredom
– aggressive behavior
– insomnia

Natural product with herbal ingredients

No side effects such as:
– drowsiness
– dizziness
– habituation

Fear and anxiety are basic emotions embedded in us for self-preservation. They mobilize us to seek better coping strategies and increase our adaptability to the environment and the changes occurring within it. The world of children, much like that of adults, is filled with problems, unfulfilled dreams, stress, and exhaustion. Regardless of their age, children experience stress and problems just as adults do, but in a slightly different way. The number of children showing signs of stress, emotional problems, and neurosis is increasing today. An indirect sign of this is the use of psychotropic substances. According to a study conducted between 2005 and 2012 in the USA and Europe and published in The European Journal Of Neuropsychopharmacology, the use of such medications increased by 40% over 7 years.
Childhood neuroses are functional disorders of the nervous system of a reversible nature. They occur with high frequency and account for about 30% of children examined by a pediatric neurologist. They are caused by exhaustion or stress (severe, one-time, or through continuous repetitive impacts on the nervous system). The still immature nervous system of children is very susceptible to external psychological influence; therefore, neurosis most often manifests for the first time in childhood. Children are very vulnerable, and logically, any negative event can leave an imprint with consequences.
Neurotic disorders are common in children and can occur at any age, in most cases due to exposure to acute or chronic stress or certain personality traits. Generally, they arise as a result of some nervous tension in children. They manifest under prolonged factors exhausting the nervous system (mental, academic, or psychological fatigue), especially in combination with another illness.
Anxiety manifests differently in different periods of a child’s development. Children with anxiety disorders are generally more insecure, depressed, isolated, and exhibit avoidant behavior. They may refuse to attend kindergarten or school. They are often irritable, with impaired concentration (especially in the afternoon, evening, or at the end of the school day), short-tempered, tearful, and have disturbed sleep with sleep-talking or nightmares. A characteristic of childhood is the close connection between mental and physical processes. Due to difficulties in expressing their emotional states in words, anxiety in children is often expressed through physical complaints (headaches, abdominal pain, shortness of breath, sweating) or through aggressive behavior. Clinically, neurosis manifests as depression, indecision, lethargy, and apathy. Complaints such as tension headaches, dizziness or “internal vertigo,” and lack of appetite are observed. Autonomic dysfunction (sweating, increased dermographism, numbness in parts of the body) is also seen. Tics or stuttering may appear. Often in children, manifestations of neurosis can be accompanied by gastrointestinal problems such as stomach pain, diarrhea, and abdominal cramps.
The link between stress and the immune system has been proven. Stress weakens the functions of innate and acquired immunity. When the stress mechanism is activated frequently or for long periods, it can significantly disrupt the balance of several systems in the body. Additionally, it reduces the ability to fight bacteria and viruses and hinders the formation of protective antibodies. It has been proven that children under the influence of stress are twice as likely to fall ill with colds.
Anxiety becomes pathological when it is more intense, more prolonged, and affects our functioning. It is advisable for parents to seek help if the child’s fears and worries become excessive and they are unable to cope with daily activities. Timely diagnosis and treatment of anxiety disorders in childhood serve as prevention for anxiety and depressive disorders in adulthood.

Main differences and advantages of SERENAMENTE JUNIOR compared to medications intended for the treatment of anxiety and sleep problems in children:
natural product based on herbal ingredients
effective for mild to moderate manifestations of stress, anxiety, and sleep problems
no negative side effects such as drowsiness or dizziness
no habituation
no withdrawal symptoms or recurrence of symptoms after stopping the preparation
very good safety profile

References:
1.Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances Julien Cases • Alvin Ibarra • Nicolas Feuille`re • Marc Roller • Samir G. Sukkar. Received: 23 November 2010/ Accepted: 2 December 2010/ Published online: 17 December 2010
2.Neuroprotective and Neurological Properties of Melissa officinalis Sara Martı, Maria Pilar Go´mez Serranillos, Maria Emilia Carretero, Anna K., Maria Isabel Calvo. Accepted: 18 April 2009/ Published online: 7 May 2009
3.Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Rodrigues Villanueva J et al. Phytother Res.2017. Mar:31(3);347-365
4.Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. Koetter U. et al. J Ethnopharmacol , 2009 Jul 30:124(3); 421-5
5.Long-term Chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial Jun J Mao a, Sharon X Xie b, John R Keefe c, Irene Soeller d, Qing S Li e, and Jay Amsterdam f
a Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
b Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, PA
c Department of Psychology, School of Arts and Sciences, University of Pennsylvania, PA
d Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, PA
e Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, PA
f Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, PA
Published in final edited form as: Phytomedicine. 2016 December 15; 23(14): 1735–1742. doi:10.1016/j.phymed.2016.10.012.
6.Bud extract from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABA A and benzodiazepine receptors activation. Allio A. et al., J Ethnopharmacol. 2015 Aug 22; 172:288-96.

Registration:
SERENAMENTE JUNIOR drops is registered with the BFSA as a food supplement under No. 3614 / 15.11.2019.

Packaging:
Cardboard box containing one 50 ml bottle with a plastic dropper cap.
Batch number: see packaging.
Net quantity: 50 ml E.

Manufacturer:
PHYTO GARDA, Italy.
PHYTO GARDA SRL
VIA S.ISIDORO, 4 – LOC. VANZELLE
37010 RIVOLI VERONESE (VR) – ITALY

Official Representative for Bulgaria:
AVENDRA PHARMA EOOD
website: www.avendrapharma.com
e-mail: info@avendrapharma.com
head office: Ruse, 3 Pleven St.
tel.: +359 888 575 008
central warehouse: Ruse, 101 Nikolaevska St.

Dosage and Administration:
Take 25 to 50 drops of the product, diluted in a little water, during the day or before bedtime. The product can also be taken undiluted directly into the mouth, preferably applied under the tongue. Shake before use.
The 50 ml bottle is sufficient for approximately 40 days at a dose of 25 drops daily and approximately 20 days at a dose of 50 drops daily.

Contraindications:
None.

Special Warnings:
Keep out of reach of children under three years of age.
Do not exceed the recommended daily dose.
Food supplements are not intended as a substitute for a varied diet and a healthy lifestyle.
Any slight variations in color and taste, and the possible formation of sediment, are due to the normal variability of ingredients of natural origin and are not an indicator of product quality deterioration.

Instructions for Use:
See dosage and administration.

Side Effects:
None known.

Shelf Life and Storage Conditions:
Store in a cool, dry place at a temperature below 25°C, away from direct sunlight and heat.
The minimum durability date refers to the product when properly stored at room temperature.
Do not use if the packaging is damaged or missing.
Use by: see the date marked on the packaging.