Effectively overcomes manifestations of:
– stress
– anxiety
– insomnia
– tension
– anxiety neurosis
– “hot flashes”
– irritability in premenstrual syndrome

Natural product with herbal ingredients
no drowsiness or dizziness
no habit-forming effects
no withdrawal syndrome

Indications:
SERENAMENTE is a means of managing the following conditions:
• mild to moderate forms of nervousness and tension
• mild to moderate forms of restlessness and anxiety
• mild sleep disturbances related to physical and mental exhaustion
• premenstrual syndrome – irritability
• menopause – hot and cold flashes
• supports natural relaxation and sleep processes
• has a beneficial effect on maintaining a normal mental state

Anxiety:
Anxiety is a term that includes several disorders manifesting as nervousness, fear, and worry. Anxiety is a very common condition among the modern population and, if not overcome, can lead to much more serious conditions. It occurs much more frequently in women compared to men.
A review of clinical studies shows that the risk of anxiety in women is twice as high compared to men [1].
This difference is due to psychological and chemical reasons. A study on the differences between men and women analyzed different types of stress responses: the development of anxiety in women involves more of the medial prefrontal-parietal cortex, while anxiety-provoking conditions in men involve a much smaller part of these structures. The higher frequency of anxiety in women also depends on certain biological factors, such as hormonal changes characteristic of different stages of a woman’s life [2].
When anxiety is mild, due to temporary causes and events, and lasts for a short period, it may pass spontaneously and gradually as the cause of the condition resolves. If it deepens with more symptoms and lasts a long time, it can seriously affect daily life and lead to serious mental and physical symptoms.
These symptoms involve the nervous, cardiovascular, muscular, and respiratory systems, and can be characterized by:
feeling of heaviness in the chest
shortness of breath
feeling of palpitations
rapid breathing
sensation of choking
difficulty swallowing
dry mouth
sensation of cold and/or hot flashes
tendency to sweat

When to resort to medication?
If the feeling of anxiety is so strong that it prevents the body from functioning normally, the use of medication would be beneficial after consulting a doctor. In modern society, there is a tendency to misuse medication. For example, the use of benzodiazepines for more than 2-4 weeks is not recommended. Habituation and dependence on benzodiazepines develop quickly, with a pronounced rebound effect /withdrawal syndrome/ of symptoms after stopping the drug. Their main disadvantages are interaction with alcohol, withdrawal syndrome, and development of dependence. Anxiolytics have a wide range of side effects that interfere with work, school, and driving.
Typical side effects of anxiolytics are:
– withdrawal syndrome
– drowsiness
– lack of energy
– slowed reflexes
– disorientation
– dizziness
– clouded judgment
– memory loss, tendency to forget
– nausea and stomach pain
– blurred and double vision
– feeling of stiffness
– confusion

A very good solution and alternative to anxiolytics for overcoming anxiety symptoms is the product SERENAMENTE.

Rosmarinic acid, one of the main active ingredients, increases levels of the neurotransmitter amino acid GABA (Gamma-aminobutyric acid), which calms brain activity, reduces stress, improves the thought process, and helps against anxiety and restlessness without habituation. GABA (Gamma-Aminobutyric Acid) is a non-essential neurotransmitter amino acid found primarily in the human brain. It improves the movement of nerve impulses by preventing neurons from overstimulating and has a number of positive effects on the nervous system. GABA has the property of calming brain waves and states associated with nervousness, improves sleep and concentration, and helps in cases of chronic anxiety. The functioning of more than half of the centers in our brain occurs thanks to this amino acid. Additional intake of supplements stimulating GABA synthesis leads to a better defensive response of the body to stress, a feeling of relaxation, and relieves symptoms of fatigue and distraction.
Lemon balm contains terpenes and flavonoids. They act at the level of the limbic system of the CNS, which coordinates vegetative functions and protects against abnormal stimuli originating from the periphery. In this way, it exerts a sedative effect that manages manifestations of vegetative dystonia [3,4].

Vitexin in the Passionflower plant is a flavonoid glycoside whose aglycone is apigenin. It interacts with a number of enzymes such as aromatase, phosphorylase A2, and acetylcholinesterase. In the brain, vitexin binds to benzodiazepine receptors, drugs known for their anxiolytic and sedative effects. Thus, vitexin possesses an effect similar to benzodiazepines: it calms the central nervous system and the sleep center [5].

Hawthorn is rich in flavonoids, proanthocyanidin, triterpenoid acids, aromatic amino acids, and cardiotonic amines. It causes arterial dilation, reduces blood pressure, slows heart rate, and strengthens cardiac contractility. It also possesses a moderate centrally acting sedative effect, useful for anxiety.

Main differences and advantages of SERENAMENTE compared to benzodiazepines:
– natural product based on herbal ingredients
– effective for mild to moderate manifestations of stress, anxiety, and sleep problems
– no negative side effects such as drowsiness or dizziness
– no habit-forming effects
– no withdrawal symptoms or rebound effects after stopping the preparation
– very good safety profile

References:
1. A systematic review of reviews on the prevalence of the anxiety disorders in adult populations. Remes O, Brayne C, van der Linde R, Lafortune L. Brain Behav. 2016 Jun 5;6(7)
2. Gender differences in neural correlates in stress-induced anxiety. Seo D, Ahluwalia A, Potenza MN, Sinha R. J Neurosci Res. 2017 Jan 2;95(1-2):115-125.
3. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Julien Cases, Alvin Ibarra, Nicolas Feuillere, Marc Roller, Samir G. Sukkar. Received: 23 November 2010/ Accepted: 2 December 2010/ Published online: 17 December 2010
4. Neuroprotective and Neurological Properties of Melissa officinalis. Sara Marti, Maria Pilar Gomez-Serranillos, Maria Emilia Carretero, Anna K., Maria Isabel Calvo. Accepted: 18 April 2009/Published online: 7 May 2009
5. A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. Gadioli IL1, da Cunha MSB1, de Carvalho MVO1, Costa AM2, Pineli LLO1. Author information:
a Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, DF, Brazil.
b Embrapa Cerrados, Laboratory of Food Science, Planaltina, Federal District, Brazil. Crit Rev Food Sci Nutr. 2018 Mar. 24:58(5):785-807.

Packaging:
Cardboard box with 30 capsules, distributed in two blisters of 15 capsules each.
Batch number: see packaging.
Net quantity: 10.9 g e.
Manufacturer:
PHYTO GARDA, Italy.
PHYTO GARDA SRL
VIA S. ISIDORO, 4 – LOC. VANZELLE
37010 RIVOLI VERONESE (VR) – ITALY
Official representative for Bulgaria:
AVENDRA PHARMA EOOD
website: www.avendrapharma.com
e-mail: info@avendrapharma.com
head office: Ruse, 3 Pleven St.
tel.: +359 888 575 008.
central warehouse: Ruse, 101 Nikolaevska St.

QUALITATIVE COMPOSITION:
Active components are a blend of extracts from: Passionflower leaves (Passiflora incarnata), Valerian root (Valeriana officinalis), Linden flower (Tilia platyphyllos), Lemon balm leaves (Melissa officinalis), California poppy whole plant (Eschscholzia californica), Hawthorn leaves and flowers (Crataegus oxyacantha) and the alkaloids contained therein: vitexin and protopine, valerenic acid.
QUANTITATIVE COMPOSITION:

The quantitative composition is for a daily intake of three capsules.
Passionflower 243 mg
Flavonoids – vitexin 8.505 mg
Valerian 243 mg
Valerenic acid 1.02 mg
Linden 243 mg
Vitexin 1.215 mg
Lemon balm 204 mg
Rosmarinic acid 8.16 mg
California poppy 135 mg
Alkaloid-protopine 0.27 mg
Hawthorn 69 mg
Vitexin 0.69 mg
EXCIPIENTS
fillers: calcium phosphate
anti-caking agents: magnesium stearate /E572/, silicon dioxide /E551/
vegetable cellulose capsule
Contains no gluten or lactose!

Dosage and administration:
Take 3 capsules daily with water, divided into two doses as follows:
1 capsule during the day and 2 capsules in the evening before sleep
Recommended daily dose: 3 capsules

Contraindications:
Do not take if you have an allergy to any of the ingredients.
Not to be taken by pregnant or breastfeeding women.

Special warnings:
Keep out of reach of children under three years of age.
Do not exceed the recommended daily dose.
Do not use as a substitute for a varied and balanced diet.
Do not use if the packaging is damaged or missing.
Use by: see date marked on the packaging.

Instructions for use:
See dosage and administration.

Side effects:
None known.

Shelf life and storage conditions:
Store in a cool, dry place,
at a temperature below 25°C, away from direct sunlight and heat.
Expiry date: see packaging.