Indications:
• Maintains the balance of normal intestinal microflora and has a beneficial effect on the natural function of the immune system.
• Helps overcome the undesirable effects of antibiotic therapy on the gastrointestinal tract.
• Helps restore B-group vitamins after taking antibiotics.
• Supports the restoration of the natural gastrointestinal flora. The use of broad-spectrum antibiotics leads to a reduction in the normal gastrointestinal flora – dysbacteriosis (a condition caused by an imbalance of the bacteria normally found in the intestines), with possible diarrhea, constipation, and the appearance of fungal infections.
• Supports the normal functioning of the intestinal microbial flora.
• Has a positive effect on the immune system.

Mechanism of action:
The safety profile of using live probiotics is still a matter of debate. The main risks include: cases of systemic infections, especially in vulnerable patients and the pediatric population; acquisition of antibiotic-resistant genes; or interference with gut colonization in newborns. To avoid these risks, there is growing interest in non-viable microorganisms or microbial cell extracts to be used as probiotics, mainly tyndallized bacteria, primarily lactic acid and bifidobacteria [1].
Tyndallized lactic acid bacteria are used in the composition of FERMENTIX JUNIOR. The combination of heat treatments with periods of lower temperatures is a process known as tyndallization, due to similarities with the sterilization method developed by the physicist Dr. John Tyndall in the 19th century.
This avoids the risks associated with live bacterial strains. Heat-treated probiotic cells are able to exert beneficial effects, mainly immunomodulatory effects, protection against enteropathogens, and maintenance of the integrity of the intestinal barrier [1].
Various strains, including lactic acid bacteria and bifidobacteria, are able to induce beneficial effects in their heat-inactivated form [2].
Heat-killed probiotics are also able to antagonize pathogens through antimicrobial compounds [3, 4].
Data show that heat-killed bacteria have key probiotic effects, with advantages over live probiotics (mainly their safety profile), making them preferred for managing common gastrointestinal discomfort in children, especially during antibiotic therapy [1].
The main effects of probiotics at the intestinal level are as follows:
Balancing and restoring the gut microbiota, protection against pathogens, immunomodulation, and maintenance of the intestinal barrier integrity;
Probiotics are able to fight pathogens by producing antimicrobial compounds;
They lower pH;
Inhibit the growth of pathogenic bacteria by directly binding to Gram-negative bacteria;
Strengthen epithelial barrier function to prevent chronic inflammation in the gut;
Probiotic lactobacilli and bifidobacteria regulate the production of inflammatory mediators and favorably regulate intestinal mucosal inflammation;
Probiotics can initiate restoration of barrier function after damage induced by various pathological conditions, such as E. coli-induced mucosal disruption;
Probiotics such as Lactobacillus and other lactic acid bacteria and bifidobacteria have been shown to inhibit a wide range of enteropathogens, including E. coli, Salmonella, Helicobacter pylori, Listeria monocytogenes, and rotavirus.
FERMENTIX JUNIOR is useful for recovery after antibiotic treatment and infections due to its content of six B-group vitamins. Vitamins of this group are of particular importance for the child’s body, and their levels decrease when the gastrointestinal tract function is impaired.
FERMENTIX JUNIOR also contains a sufficient amount of arabinogalactan. Arabinogalactans are biologically active compounds (prebiotics). Arabinogalactan is an excellent immune system stimulator. Arabinogalactan stimulates the formation of immune cells twice as effectively as echinacea. FERMENTIX JUNIOR supports the child’s immunity, weakened during illness.
Effects of Arabinogalactan:
stimulates the growth and development of beneficial intestinal microflora;
improves intestinal peristalsis;
promotes regular cleansing of the intestinal tract;
absorbs and removes toxic substances, radionuclides, and heavy metals;
strengthens the immune system;
protects against the negative consequences of antibiotic therapies, protecting the beneficial intestinal microflora from the damaging effects of the antibiotic. Microbial arabinogalactan is a major structural component of the mycobacterial cell wall [3];
contributes to increasing the therapeutic effect when used simultaneously with probiotic preparations containing lacto- and bifidobacteria;
Arabinogalactan is effective for modulating the immune response to the invasion of pathogenic microorganisms [4].

REFERENCES:
1. Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview, Published: 23 May 2019. Núria Piqué, Mercedes Berlanga, David Miñana-Galbis. Microbiology Section, Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona (UB), Av Joan XXIII, 27-31, 08028 Barcelona, Catalonia, Spain; mberlanga@ub.edu (M.B.); davidminyana@ub.edu (D.M.-G.). Institut de Recerca en Nutrició i Seguretat Alimentària de la UB (INSA-UB), Universitat de Barcelona
2. Para-probiotics for Preterm Neonates—The Next Frontier Girish Deshpande 1,2, Gayatri Athalye-Jape 3 and Sanjay Patole 3, Department of Neonatology, Nepean Hospital, Kingswood, NSW 2747, Australia; girish.deshpande@health.nsw.gov.au 2 Sydney Medical School Nepean, University of Sydney, Kingswood, NSW 2747, Australia 3 Department of Neonatology, King Edward Memorial Hospital for Women, Perth, WA 6008, Australia; gayatri.jape@health.wa.gov.au * Correspondence: sanjay.patole@health.wa.gov.au; Tel.: +61-8-6458-1260 Received: 29 April 2018; Accepted: 2 July 2018; Published: 5 July 2018
3. Jump up to: a b c d e Bhamidi S (2009). „Mycobacterial Cell Wall Arabinogalactan“. Bacterial Polysaccharides: Current Innovations and Future Trends. Caister Academic Press. ISBN 978-1-904455-45-5.
4. Udani et al., 2010, Germany.

Packaging:
Cardboard box with 12 oral vials of 10 ml each.
Batch number: see packaging
Net quantity: 120 ml E.

Manufacturer:
PHYTO GARDA, Italy.
PHYTO GARDA SRL
VIA S.ISIDORO, 4 – LOC. VANZELLE
37010 RIVOLI VERONESE (VR) – ITALY

Official representative for Bulgaria:
AVENDRA PHARMA EOOD
website: www.avendrapharma.com
e-mail: info@avendrapharma.com
head office: 3 Pleven St., Ruse
tel.: +359 888 575 008.
central warehouse: 101 Nikolaevska St., Ruse

QUANTITATIVE COMPOSITION:
Content in the recommended daily dose (2 vials):
Ingredients: 1 vial (10 ml) 2 vials (20 ml)
Arabinogalactan 250 mg 500 mg
Tyndallized lactic acid bacteria
Lactobacillus acidophilus 4 x 10⁹ cfu/g 8 x 10⁹ cfu/g
Lactobacillus casei 1 x 10⁹ cfu/g 2 x 10⁹ cfu/g
B-group vitamins
Vitamin B3 4.8 mg 9.6 mg
Vitamin B2 0.42 mg 0.84 mg
Vitamin B6 0.42 mg 0.84 mg
Vitamin B1 0.33 mg 0.66 mg
Vitamin B12 0.75 µg 1.5 µg
May contain traces of soy and lactose.
Gluten-free.

EXCIPIENTS:
water
sweetener: fructose
preservatives: citric acid /E330/, potassium sorbate /E202/, sodium benzoate /E211/
flavor

Dosage and administration:
Take 1–2 vials daily, with or without further dissolving the contents in liquid.
Take between meals or after a meal.
Shake the vial well before use.

Contraindications:
Do not take if you have a known allergy to any of the ingredients.

Special warnings:
Do not exceed the recommended daily dose.
Do not use in children under 3 years of age.
Do not use as a substitute for a varied and balanced diet.
Keep out of reach of young children.
You may notice a change in color, smell, or observe a sediment at the bottom of the vial, which disappears upon shaking. This is a natural result of the nature of the ingredients used and does not mean the product is unfit for use.

Instructions for use:
See dosage and administration.

Side effects:
None known.

Shelf life and storage conditions:
Store in a cool, dry place at temperatures up to 25°C, away from sunlight.
Do not use if the packaging is damaged or missing.
Use by: see the date marked on the packaging.