{"id":41712,"date":"2024-09-24T12:03:26","date_gmt":"2024-09-24T12:03:26","guid":{"rendered":"https:\/\/avendrapharma.com\/produkt\/fermentix-junior-oral-solution-10-ml-x-12-vials\/"},"modified":"2024-09-24T12:03:26","modified_gmt":"2024-09-24T12:03:26","slug":"fermentix-junior-oral-solution-10-ml-x-12-vials","status":"publish","type":"product","link":"https:\/\/avendrapharma.com\/en\/produkt\/fermentix-junior-oral-solution-10-ml-x-12-vials\/","title":{"rendered":"Fermentix Junior, oral solution, 10 ml x 12 vials"},"content":{"rendered":"

Indications<\/strong>:
\n\u2022 Maintains the balance of normal intestinal microflora and has a beneficial effect on the natural function of the immune system.
\n\u2022 Helps overcome the undesirable effects of antibiotic therapy on the gastrointestinal tract.
\n\u2022 Helps restore B-group vitamins after taking antibiotics.
\n\u2022 Supports the restoration of the natural gastrointestinal flora. The use of broad-spectrum antibiotics leads to a reduction in the normal gastrointestinal flora – dysbacteriosis (a condition caused by an imbalance of the bacteria normally found in the intestines), with possible diarrhea, constipation, and the appearance of fungal infections.
\n\u2022 Supports the normal functioning of the intestinal microbial flora.
\n\u2022 Has a positive effect on the immune system.<\/p>\n

Mechanism of action:<\/strong>
\nThe safety profile of using live probiotics is still a matter of debate. The main risks include: cases of systemic infections, especially in vulnerable patients and the pediatric population; acquisition of antibiotic-resistant genes; or interference with gut colonization in newborns. To avoid these risks, there is growing interest in non-viable microorganisms or microbial cell extracts to be used as probiotics, mainly tyndallized bacteria, primarily lactic acid and bifidobacteria [1].
\nTyndallized lactic acid bacteria are used in the composition of FERMENTIX JUNIOR. The combination of heat treatments with periods of lower temperatures is a process known as tyndallization, due to similarities with the sterilization method developed by the physicist Dr. John Tyndall in the 19th century.
\nThis avoids the risks associated with live bacterial strains. Heat-treated probiotic cells are able to exert beneficial effects, mainly immunomodulatory effects, protection against enteropathogens, and maintenance of the integrity of the intestinal barrier [1].
\nVarious strains, including lactic acid bacteria and bifidobacteria, are able to induce beneficial effects in their heat-inactivated form [2].
\nHeat-killed probiotics are also able to antagonize pathogens through antimicrobial compounds [3, 4].
\nData show that heat-killed bacteria have key probiotic effects, with advantages over live probiotics (mainly their safety profile), making them preferred for managing common gastrointestinal discomfort in children, especially during antibiotic therapy [1].
\nThe main effects of probiotics at the intestinal level are as follows:
\nBalancing and restoring the gut microbiota, protection against pathogens, immunomodulation, and maintenance of the intestinal barrier integrity;
\nProbiotics are able to fight pathogens by producing antimicrobial compounds;
\nThey lower pH;
\nInhibit the growth of pathogenic bacteria by directly binding to Gram-negative bacteria;
\nStrengthen epithelial barrier function to prevent chronic inflammation in the gut;
\nProbiotic lactobacilli and bifidobacteria regulate the production of inflammatory mediators and favorably regulate intestinal mucosal inflammation;
\nProbiotics can initiate restoration of barrier function after damage induced by various pathological conditions, such as E. coli-induced mucosal disruption;
\nProbiotics such as Lactobacillus and other lactic acid bacteria and bifidobacteria have been shown to inhibit a wide range of enteropathogens, including E. coli, Salmonella, Helicobacter pylori, Listeria monocytogenes, and rotavirus.
\nFERMENTIX JUNIOR is useful for recovery after antibiotic treatment and infections due to its content of six B-group vitamins. Vitamins of this group are of particular importance for the child’s body, and their levels decrease when the gastrointestinal tract function is impaired.
\nFERMENTIX JUNIOR also contains a sufficient amount of arabinogalactan. Arabinogalactans are biologically active compounds (prebiotics). Arabinogalactan is an excellent immune system stimulator. Arabinogalactan stimulates the formation of immune cells twice as effectively as echinacea. FERMENTIX JUNIOR supports the child’s immunity, weakened during illness.
\nEffects of Arabinogalactan:
\nstimulates the growth and development of beneficial intestinal microflora;
\nimproves intestinal peristalsis;
\npromotes regular cleansing of the intestinal tract;
\nabsorbs and removes toxic substances, radionuclides, and heavy metals;
\nstrengthens the immune system;
\nprotects against the negative consequences of antibiotic therapies, protecting the beneficial intestinal microflora from the damaging effects of the antibiotic. Microbial arabinogalactan is a major structural component of the mycobacterial cell wall [3];
\ncontributes to increasing the therapeutic effect when used simultaneously with probiotic preparations containing lacto- and bifidobacteria;
\nArabinogalactan is effective for modulating the immune response to the invasion of pathogenic microorganisms [4]. <\/p>\n

REFERENCES:<\/strong>
\n1. Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview, Published: 23 May 2019. N\u00faria Piqu\u00e9, Mercedes Berlanga, David Mi\u00f1ana-Galbis. Microbiology Section, Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona (UB), Av Joan XXIII, 27-31, 08028 Barcelona, Catalonia, Spain; mberlanga@ub.edu (M.B.); davidminyana@ub.edu (D.M.-G.). Institut de Recerca en Nutrici\u00f3 i Seguretat Aliment\u00e0ria de la UB (INSA-UB), Universitat de Barcelona
\n2. Para-probiotics for Preterm Neonates\u2014The Next Frontier Girish Deshpande 1,2, Gayatri Athalye-Jape 3 and Sanjay Patole 3, Department of Neonatology, Nepean Hospital, Kingswood, NSW 2747, Australia; girish.deshpande@health.nsw.gov.au 2 Sydney Medical School Nepean, University of Sydney, Kingswood, NSW 2747, Australia 3 Department of Neonatology, King Edward Memorial Hospital for Women, Perth, WA 6008, Australia; gayatri.jape@health.wa.gov.au * Correspondence: sanjay.patole@health.wa.gov.au; Tel.: +61-8-6458-1260 Received: 29 April 2018; Accepted: 2 July 2018; Published: 5 July 2018
\n3. Jump up to: a b c d e Bhamidi S (2009). \u201eMycobacterial Cell Wall Arabinogalactan\u201c. Bacterial Polysaccharides: Current Innovations and Future Trends. Caister Academic Press. ISBN 978-1-904455-45-5.
\n4. Udani et al., 2010, Germany. <\/p>\n

Packaging:<\/strong>
\nCardboard box with 12 oral vials of 10 ml each.
\nBatch number: see packaging
\nNet quantity: 120 ml E.<\/p>\n

Manufacturer:<\/strong>
\nPHYTO GARDA, Italy.
\nPHYTO GARDA SRL
\nVIA S.ISIDORO, 4 \u2013 LOC. VANZELLE
\n37010 RIVOLI VERONESE (VR) \u2013 ITALY <\/p>\n

Official representative for Bulgaria:<\/strong>
\nAVENDRA PHARMA EOOD
\nwebsite: www.avendrapharma.com
\ne-mail: info@avendrapharma.com
\nhead office: 3 Pleven St., Ruse
\ntel.: +359 888 575 008.
\ncentral warehouse: 101 Nikolaevska St., Ruse<\/p>\n

 <\/p>\n

QUANTITATIVE COMPOSITION:<\/strong>
\nContent in the recommended daily dose (2 vials):
\nIngredients: 1 vial (10 ml) 2 vials (20 ml)
\nArabinogalactan 250 mg 500 mg
\nTyndallized lactic acid bacteria
\nLactobacillus acidophilus 4 x 10\u2079 cfu\/g 8 x 10\u2079 cfu\/g
\nLactobacillus casei 1 x 10\u2079 cfu\/g 2 x 10\u2079 cfu\/g
\nB-group vitamins
\nVitamin B3 4.8 mg 9.6 mg
\nVitamin B2 0.42 mg 0.84 mg
\nVitamin B6 0.42 mg 0.84 mg
\nVitamin B1 0.33 mg 0.66 mg
\nVitamin B12 0.75 \u00b5g 1.5 \u00b5g
\nMay contain traces of soy and lactose.
\nGluten-free.<\/p>\n

EXCIPIENTS:<\/strong>
\nwater
\nsweetener: fructose
\npreservatives: citric acid \/E330\/, potassium sorbate \/E202\/, sodium benzoate \/E211\/
\nflavor<\/p>\n

 <\/p>\n

Dosage and administration:<\/strong>
\nTake 1\u20132 vials daily, with or without further dissolving the contents in liquid.
\nTake between meals or after a meal.
\nShake the vial well before use.<\/p>\n

Contraindications:<\/strong>
\nDo not take if you have a known allergy to any of the ingredients.<\/p>\n

Special warnings:<\/strong>
\nDo not exceed the recommended daily dose.
\nDo not use in children under 3 years of age.
\nDo not use as a substitute for a varied and balanced diet.
\nKeep out of reach of young children.
\nYou may notice a change in color, smell, or observe a sediment at the bottom of the vial, which disappears upon shaking. This is a natural result of the nature of the ingredients used and does not mean the product is unfit for use. <\/p>\n

Instructions for use:<\/strong>
\nSee dosage and administration.<\/p>\n

Side effects:<\/strong>
\nNone known.<\/p>\n

Shelf life and storage conditions:<\/strong>
\nStore in a cool, dry place at temperatures up to 25\u00b0C, away from sunlight.
\nDo not use if the packaging is damaged or missing.
\nUse by: see the date marked on the packaging.<\/p>\n","protected":false},"excerpt":{"rendered":"

FERMENTIX JUNIOR is a SYNBIOTIC (a combination of probiotics and a prebiotic) containing tyndallized (heat-treated) bacteria with added B-group vitamins and arabinogalactan. Suitable for restoring the child’s body after antibiotic therapy, as well as during and after gastrointestinal discomfort, with an excellent safety and tolerance profile. Available in convenient mini oral vials with a gentle taste preferred by children. <\/p>\n","protected":false},"featured_media":41715,"template":"","meta":[],"product_brand":[],"product_cat":[194,195,183],"product_tag":[],"class_list":["post-41712","product","type-product","status-publish","has-post-thumbnail","product_cat-all-products","product_cat-childrens-health","product_cat-uncategorized","description-off","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/product\/41712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/media\/41715"}],"wp:attachment":[{"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/media?parent=41712"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/product_brand?post=41712"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/product_cat?post=41712"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/avendrapharma.com\/en\/wp-json\/wp\/v2\/product_tag?post=41712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}