SERENAMENTE JUNIOR
effective in the following conditions in children:
without side effects such as:
intake: 25 to 50 drops diluted in a little water during the day or at bedtime
MANUFACTURER: PHYTO GARDA, ITALY
SERENAMENTE JUNIOR s a food supplement designed to treat the symptoms of anxiety, irritability, nervousness and insomnia in children. Supports the natural processes of relaxation and sleep. Has a beneficial effect on maintaining the normal state of mind. Food supplement formulated with plant extracts. Chamomile, Linden and Jujube promote relaxation and sleep. Lemon balm promotes normal mood tone and, as well as Chamomile and Jujube, supports mental wellness.
Lemon balm (Melissa officinalis L., leaf), rosemary acid, Jujube (Ziziphus jujube Miller, seeds), triterpenoid saponins, Chamomile (Matricaria, flower heads), apigenin, Linden (flowers of Tilia platyphyllos Scopoli 90% and Tilia cordata Miller %), flavonoids
| Ingredients | Quantity in one dose of 25 drops | Quantity in one dose of 50 drops |
| Lemon balm (Melissa officinalis) | 20 mg | 40 mg |
| Rosemary acid | 0,8 mg | 1,6 mg |
| Jujube (Ziziphus) | 20 mg | 40 mg |
| Triterpenoid saponins | 0,4 mg | 0,8 mg |
| Chamomile (Matricaria Chamomilla) | 20 mg | 40 mg |
| Apigenin | 0,06 mg | 0,12 mg |
| Linden, цвят (Tilia) | 10 mg | 20 mg |
| Flavonoids | 0,1 mg | 0,2 mg |
water
fructose (28%)
fragrances
acidity regulator: citric acid
preservative: potassium sorbate
thickener: xanthan gum
SERENAMENTE JUNIOR is a remedy for controlling the following conditions in children:
Fear and anxiety are basic emotions embedded in us for the purpose of self-preservation. They mobilize us to look for better coping strategies and increase our adaptability to the environment and the changes that occur in it. The world of children, like that of adults, is full of problems, unfulfilled dreams, stress and fatigue. Regardless of their age, children experience stress and problems in the same way as adults, but in a slightly different way. The number of children with manifestations of stress, emotional problems and neurosis is growing nowadays. An indirect sign of this is the use of psychotropic drugs. According to a study conducted between 2005 and 2012 in the United States and Europe and published in The European Journal Of Neuropsychopharmacology, the use of such drugs has increased by 40% in 7 years.
Childhood neuroses are reversible functional disorders of the nervous system. They are very common and make up about 30% of the children examined by a pediatric neurologist. They are caused by fatigue or stress (strong, one-time or with continuous effects on the nervous system). The still immature nervous system of children is very susceptible to psychological influences from the outside, therefore the neurosis most often manifests itself for the first time in childhood. Children are very vulnerable and logically any negative event can leave a mark with consequences.
Neurotic disorders are common in children and can occur at any age, in most cases when exposed to acute or chronic stress or certain personality traits. They generally occur as a result of some nervous tension in children. They are manifested by long-term debilitating factors (mental, educational, mental fatigue), especially in combination with other diseases.
Anxiety manifests itself differently in different periods of a child's development. Children with anxiety disorders are generally more insecure, depressed, isolated, and avoidant. They may refuse to attend kindergarten or school. They are often irritable, with impaired concentration (especially in the afternoon, evening, at the end of the school day), irritable, crying, with disturbed sleep with delusions or nightmares. Characteristic of childhood is the close connection of mental and physical processes. Due to the difficulty in expressing their emotional states in words, anxiety in children is often expressed through physical complaints (headache, abdominal pain, shortness of breath, sweating) or through aggressive manifestations. Clinically, the neurosis is manifested by depression, indecision, lethargy, apathy. There are complaints such as tension headache, dizziness or "internal dizziness", loss of appetite. There is also autonomic dysfunction (sweating, increased dermographism, tingling in parts of the body). Tics or stuttering may occur. neurosis can also be accompanied by problems with the gastrointestinal tract such as stomach pain, upset and cramps in the abdomen.
The link between stress and the immune system has been proven. Stress weakens the functions of innate and acquired immunity. When the stress mechanism is activated frequently or for long periods of time, it can significantly upset the balance of work of a number of systems in the body. It further reduces the ability to fight bacteria and viruses and makes it difficult to form protective antibodies. It has been proven that children under the influence of stress are twice as likely to get colds.
Anxiety becomes pathological when it is more intense, longer lasting and affects our functioning. It is good for parents to seek help if the child's fears and worries become excessive and he is unable to cope with his daily activities. Timely diagnosis and treatment of anxiety disorders in childhood is the prevention of anxiety and depressive disorders in adulthood.
Lemon balm
Lemon balm with its alkaloids has a pronounced sedative activity, removing the feeling of excitement and tension. Lemon balm extract improves sleep quality, calms the mind and improves mood without negative side effects such as drowsiness or dizziness. Lemon balm has a beneficial effect on the nervous system due to its effect on GABA receptors, as well as on serotonin, and studies show that this is due to the rosemary acid it contains. Rosemary acid increases the levels of the neurotransmitter amino acid GABA (Gamma-aminobutyric acid), which calms brain activity, reduces stress, improves the thought process and helps against anxiety and worry without getting used to it. This is why the herb helps to fall asleep easily. Rosemary acid also has antiviral activity. Separately, balm has a beneficial effect on the stomach and digestive problems, which often affect sleep. Lemon balm intake improves sleep in people with insomnia and midnight awakening. The effect is also very important in children, because the balm has a mild effect and does not lead to addiction. This is its huge advantage over heavier medications, which are often prescribed at an early age and have an effect on children's development. The use of balm helps in hyperactive children with unsustainable attention. Unlike other preparations, balm does not reduce performance, but on the contrary - improves cognitive abilities and increases attention. Research shows that taking no balm extract improves mental ability in solving problems related to memory, math, and concentration. The influence of the receptors, as well as the set of antispasmodic ingredients in the balm make it extremely suitable for headaches, especially when the headache is due to muscle cramps / tension headache /. Lemon balm also has a pronounced beneficial effect on a wide range of digestive problems such as upset stomach, bloating, vomiting, pain, etc.
GABA (Gamma-Aminobutyric Acid) is an abbreviation for gamma-aminobutyric acid or also known as gamma-aminobutyric acid. It is a non-essential, neurotransmitter amino acid that is naturally synthesized primarily in the human brain. GABA improves the movement of nerve impulses by preventing neurons (cells of the central nervous system) from being overstimulated, ie. plays the role of a mediator that reduces the excitatory mental processes in the brain. This hyperexcitability of neurons could otherwise manifest itself as anxiety, insomnia, headaches, seizures, muscle cramps, mental disorders, tics and more. In the human body, GABA calms brain waves in states of nervousness and anxiety, improves concentration and thought process and induces sleep. GABA has a natural calming effect, reducing the feeling of fear and anxiety by weakening the excitability of neurons. Decreased GABA production is reported in people who are exposed to stress. The same problem is observed in people who are very tense or overworked. If GABA levels are normal, then sleep is also calm and normal. This neurotransmitter is also thought to play a role in depression, as studies have found that people with depression tend to have lower levels of GABA. Panic attacks, addictions, cognitive impairment and many other conditions are also associated with low GABA activity. Other studies show that GABA increases the concentration of human growth hormone (HGH), which contributes to better muscle strength, healthier bones and a lower risk of heart disease. GABA, leads to a better protective response of the body to stress, a feeling of relaxation and relieves symptoms of fatigue, anxiety and distraction.
Rosemary acid, which is one of the main active ingredients in JUNIOR SERENAMENT, has been shown to increase GABA levels, which in turn has a number of positive effects on the nervous system and reduces stress and eliminates anxiety. This is because rosemary acid inhibits (counteracts) a certain enzyme (GABA-transaminase) in the human body, which leads to the breakdown of GABA. By blocking this enzyme that destroys rosmarinic acid, it helps increase the amount of GABA in the brain, which in turn increases the positive effect of GABA by reducing neuronal excitability and calming the mind. Studies have shown that rosmarinic acid, of all plant extracts, has the strongest inhibitory ability against GABA-transaminase, which favors the feeling of mental comfort and relieves nervous tension.
Jujuba
Jujuba is of Asian origin. It contains triterpenoid saponins, isoquinoline alkaloids / zizifuzin /, cyclopeptides, flavonoids, tannins, vitamins, minerals and amino acids. The flavonoids in jujube have strong antioxidant, anti-inflammatory and anti-tumor properties, which help reduce the risk of a number of chronic diseases. The anxiolytic and sedative effect of jujube is associated with the effect of serotonin in the CNS. Reduces waking at night and improves sleep. Its anxiolytic and sedative effect has been associated with effects on the serotonin system. According to a number of phytotherapists, the five most useful medicinal plants in the world definitely include jujube, which is not widespread and almost unknown in our country.
Camomile
It has antispasmodic and sedative effects. Its effective ingredients are flavonoids and the alkaloid apigenin. Flavonoids bind to benzodiazepine receptors and have a sedative effect. Flavonoids promote good sleep, have anxiolytic action and have an antispasmodic effect on the smooth muscles of the gastrointestinal tract. Apigenin reduces the symptoms of depression and anxiety. In addition, clinical data demonstrate the very good effect of apigenin in treating insomnia. In children, they are used to relax and improve sleep. Chamomile relaxes the nervous system and acts as an anti-inflammatory. It helps with irritations of the nervous system because it has the ability to relax it. Successfully reduces anxiety, restlessness and insomnia. This makes it a good helper in the prevention of depression and diseases associated with increased levels of stress in the body. It also reduces headaches.
Linden
Linden has a sedative and antispasmodic effect. Linden flowers contain the flavonoids quercetin and kaempferol. They affect the manifestations of stress and nervousness. They also have a calming and antispasmodic effect on the smooth muscles of the gastrointestinal tract. The combination of compounds and chemicals found in linden reduces stomach discomfort. These effects are associated with terpenes, which have been shown to reduce spontaneous intestinal hyperactivity and suppress duodenal and small bowel spasms caused by acetylcholine. The sedative effect that flavonoids in linden have is used in manifestations of stress and neurosis. Linden is a proven remedy against anxiety, frequent mood swings and chronic stress. It has a calming effect, especially before sleep or with increased excitability, especially in children, where other medications are not recommended. It also helps effectively with tension headaches and inflammatory processes.
1.Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances Julien Cases • Alvin Ibarra • Nicolas Feuille`re • Marc Roller • Samir G. Sukkar. Received: 23 November 2010/ Accepted: 2 December 2010/ Published online: 17 December 2010
2.Neuroprotective and Neurological Properties of Melissa officinalis Sara Martı, Maria Pilar Go´mez Serranillos, Maria Emilia Carretero, Anna K., Maria Isabel Calvo. Accepted: 18 April 2009/ Published online: 7 May 2009
3.Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Rodrigues Villanueva J et al. Phytother Res.2017. Mar:31(3);347-365
4.Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. Koetter U. et al. J Ethnopharmacol , 2009 Jul 30:124(3); 421-5
5.Long-term Chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial Jun J Mao a, Sharon X Xie b, John R Keefe c, Irene Soeller d, Qing S Li e, and Jay Amsterdam f
a Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
b Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, PA
c Department of Psychology, School of Arts and Sciences, University of Pennsylvania, PA
d Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, PA
e Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, PA
f Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, PA
Published in final edited form as: Phytomedicine. 2016 December 15; 23(14): 1735–1742. doi:10.1016/j.phymed.2016.10.012.
6.Bud extract from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABA A and benzodiazepine receptors activation. Allio A. et al., J Ethnopharmacol. 2015 Aug 22; 172:288-96.
Take 25 to 50 drops of the product, diluted in a little water, during the day or at bedtime. The product can be taken undiluted directly in the mouth, it is better to apply under the tongue. Shake before use.
The 50 ml bottle is sufficient for about 40 days at a dose of 25 drops per day and approximately 20 days at a dose of 50 drops per day.
None.
Keep out of reach of children under three years of age.
Do not exceed the recommended daily dose.
Nutritional supplements are not intended as a substitute for a varied diet and a healthy lifestyle.
Any slight deviations in color and taste and the possible formation of precipitates are due to the normal variability of the ingredients of natural origin and is not an indicator of deterioration of the product.
Not known.
Store in a cool, dry place, below 25 ° C, away from direct sunlight and heat.
The date of minimum durability refers to the product when stored properly at room temperature.
Do not use if package is damaged or missing.
Use before: see the date marked on the package.
SERENAMENTE JUNIOR is registered in the BFSA as a food supplement under №3614 / 15.11.2019.
Cardboard box, with one bottle of 50 ml. with plastic cap with dropper.
Batch number: see package.
Net quantity: 50ml E.
PHYTO GARDA SRL
Via Europa Unita 1A/4 - 37011 Bardolino (VR) - ITALY
tel. +39 0456770222
info@phytogarda.it
P. IVA: 03321240230
AVENDRA PHARMA Ltd.
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Phone: +359888575008
www.avendrapharma.com
info@avendrapharma.com
