SERENAMENTE CAPSULES
effectively overcomes the symptoms of:
without signs of drowsiness and dizziness
without manifestations of habituation
without withdrawal syndrome
intake: 1 capsule during the day and 2 capsules in the evening
MANUFACTURER: PHYTO GARDA, ITALY
Food supplement formulated with plant extracts. SERENAMENTE capsules is a dietary supplement designed to overcome the manifestations of anxiety, worry, stress and insomnia. Valerian, Linden and California poppy help encourage relaxation in moments of stress and give an untroubled sleep. Lemon balm and Passionflower foster mental wellbeing. Hawthorn in addition regulates the functioning of the cardiovascular system.
The active ingredients are a mixture of extracts of: Passiflora leaves (Passiflora incarnata), Valeriana root (Valeriana officinalis), Tilia flower (Tilia platyphyllus), Melissa leaves (Melissa officinalis), California poppy whole plant (Eschscholzia californica), Hawthorn blossom (Crataegus oxyacantha) and the alkaloids contained in them: vitexin and protopine, rosemary and valeric acid.
The quantitative composition is for the daily intake of three capsules.
| Passiflora incarnata | 243 mg |
| Flavonoids - vitexin | 8,505 mg |
| Valeriana officinalis | 243 mg |
| Valeric acid | 1,02 mg |
| Tilia platyphyllus | 243 mg |
| Vitexin | 1,215 mg |
| Melissa officinalis | 204 mg |
| Rosemary acid | 8,16 mg |
| Eschscholzia californica | 135 mg |
| Alkaloid - protopine | 0,27 mg |
| Crataegus oxyacantha | 69 mg |
| Vitexin | 0,69 mg |
fillers: calcium phosphate
anti-caking agents: magnesium stearate / E572 /, silicon dioxide / E551 /
vegetable cellulose capsule
Free of gluten and lactose!
SERENAMENTE is a remedy for controlling the following conditions:
• mild to moderate forms of nervousness and tension
• mild to moderate forms of anxiety
• mild sleep disorders associated with physical and mental fatigue
• premenstrual syndrome - irritability
• menopause - hot and cold waves
• supports the natural processes of relaxation and sleep
• has a beneficial effect on maintaining the normal state of mind
Anxiety is a term that includes several disorders manifested by nervousness, fear, anxiety. Anxiety is a very common condition among the modern population and if not overcome can lead to much more serious conditions.
A review of clinical trials shows that the risk of anxiety in women is twice as high as in men [1].
This difference is due to psychological and chemical reasons. A study on the differences between men and women analyzed the different types of stress response: the development of anxiety in women involved more of the medial prefrontal-parietal cortex, while anxiety-provoking conditions in men involved much less of these structures. The higher frequency of anxiety in women also depends on some biological factors, such as hormonal changes characteristic of different stages of women's lives [2].
When anxiety is mild, due to temporary causes and events, and is for a short period of time, it can pass spontaneously and gradually with the passage of the cause that led to this condition. If it worsens with more symptoms and lasts for a long time, it can seriously affect daily life and lead to serious mental and physical symptoms.
These symptoms involve the nervous system, cardiovascular system, muscular and respiratory systems, and can be characterized by:
If the feeling of anxiety is so strong that it prevents the body from functioning normally, the use of medication would be beneficial after consulting a doctor. In modern society there is a tendency to abuse drugs. For example, the use of benzodiazepines for more than 2-4 weeks is not recommended. Addiction and dependence to benzodiazepines with a pronounced effect of recurrence (withdrawal syndrome) of symptoms after discontinuation of the drug can develop rapidly. Their main disadvantages are the interaction with alcohol, withdrawal syndrome and the development of addiction. Anxiolytics have a wide range of side effects that interfere with work, school and driving.
Typical side effects of anxiolytics are:
A very good solution and alternative to anxiolytics to overcome the symptoms of anxiety is the product SERENAMENTE.
Rosemary acid, which is one of the main active ingredients, increases the levels of the neurotransmitter amino acid GABA (Gamma-aminobutyric acid), which calms brain activity, reduces stress, improves the thought process and helps against anxiety and worry without getting used to it. GABA (Gamma-Aminobutyric Acid) is a non-essential neurotransmitter amino acid found primarily in the human brain. It improves the movement of neural impulses by preventing neurons from being overstimulated and has a number of positive effects on the nervous system. GABA has the ability to calm brain waves and conditions associated with nervousness, improves sleep and concentration and helps in cases of chronic anxiety. The functioning of more than half of the centers in our brain happens thanks to this amino acid. The additional intake of supplements that stimulate the synthesis of GABA leads to a better protective response of the body to stress, a feeling of relaxation and relieves the symptoms of fatigue and distraction.
Lemon balm contains terpenes and flavonoids. They act at the level of the limbic system of the CNS, which coordinates the autonomic functions and protects against abnormal stimuli originating from the periphery. In this way it has a sedative effect, which controls the manifestations of vegetative dystonia [3, 4].
The vitexin in the Passionflower plant is a flavonoid glycoside whose aglycone is apigenin. It interacts with a number of enzymes such as aromatase, phosphorylase A2 and acetylcholinesterase. In the brain, vitexin binds to benzodiazepine receptors, drugs known for their anxiolytic and sedative effects. Thus, Vitexin has a benzodiazepine-like effect: it calms the central nervous system and the sleep center [5].
Hawthorn is rich in flavonoids, proanthocyanidins, triterpenoic acids, aromatic amino acids and cardiotonic amines. Causes arterial dilation, lowers blood pressure, slows heart rate, increases cardiac contractility. It also has a moderate centrally acting sedative effect, useful for anxiety.
Main differences and advantages of SERENAMENTE compared to benzodiazepines:
1.A systematic review of reviews on the prevalence of the anxiety disorders in adults populations. Remes O, Brayne C, van der Linde R, Lafortune L Brain behav.2006 Jun 5;6(7)
2.Gender differences in neural correlates in stress-induced anxiety. Seo D, Ahluwalia A, Potenza MN, Sinha R.J Neurosci Res.2017 Jan 2;95(1-2):115-125.
3.Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to moderate anxiety disorders and sleep disturbances. Julien Cases • Alvin Ibarra • Nicolas Feuille`re • Marc Roller • Samir G. Sukkar. Received: 23 November 2010/ Accepted: 2 December 2010/ Published online: 17 December 2010
4.Neuroprotective and Neurological Properties of Melissa officinalis. Sara Martı, Maria Pilar Go´mez-Serranillos ,Maria Emilia Carretero, Anna K. ,Maria Isabel Calvo. Accepted: 18 April 2009/Published online: 7 May 2009
5.A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. Gadioli IL1, da Cunha MSB1, de Carvalho MVO1, Costa AM2, Pineli LLO1. Author information:
a Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, DF, Brazil.
b Embrapa Cerrados, Laboratory of Food Science, Planaltina, Federal District , Brazil. Crit Rev Food Sci Nutr.2018 Mar. 24:58(5):785-807.
Take 3 capsules daily with water, divided into two doses as follows:
1 capsule during the day and 2 capsules in the evening before bedtime
Recommended daily dose: 3 capsules
Do not take if you are allergic to any of the ingredients.
Do not take if you are pregnant or lactating woman.
Keep out of reach of children up to three years.
Do not exceed the recommended daily dose.
Do not use as a substitute for a varied and rational diet.
Do not use if package is damaged or missing.
Use before: see the date marked on the package.
Not known.
Store in a cool, dry place,
at temperatures below 25 ° C, away from direct sunlight and heat.
Shelf life: see package.
Cardboard box with 20 capsules, divided into two blisters of 10 capsules.
Batch number: see package.
Net quantity: 10.9 g.
PHYTO GARDA SRL
Via Europa Unita 1A/4 - 37011 Bardolino (VR) - ITALY
tel. +39 0456770222
info@phytogarda.it
P. IVA: 03321240230
AVENDRA PHARMA Ltd.
Bulgaria 7000, Ruse, Pleven str, 3
Phone: +359888575008
www.avendrapharma.com
info@avendrapharma.com
