Macushield is a nutritional supplement that supports normal retinal function, thus improving the quality of vision. Macushield is especially suitable for patients at risk of macular pigment damage or already have initial manifestations of macular pigment damage.
Nutritional Information
Meso-Zeaxanthin: 10mg
Lutein: 10mg
Zeaxanthin: 2mg
Ingredients List
Sunflower Seed Oil, Capsule Shell (Gelatin, Glycerol, Beeswax, Colour: Red Iron Oxide), Marigold Extract, Beeswax
*Original Formula and Original Formula Vegetarian – Based on UK survey data of 92 eye experts
INDICATIONS:
Macushield is suitable for all people at risk of macular pigment damage or already have signs of macular pigment damage.
Macushield is suitable for people with high visual load, who work for a long time on computers, screens and other similar electronic devices.
Macushield is suitable for people performing activities related to document processing, in which the vision is loaded for a long time, without the possibility of rest.
Macushield is suitable for people whose work or activity is associated with prolonged exposure to bright sunlight or bright artificial light.
MECHANISM OF ACTION:
Macular degeneration is the most common cause of vision loss in developed countries. It is due to degenerative changes in the macula, which are associated with certain pathophysiological processes leading to a decrease in the amount of pigment in the macula. The risk factors that underlie macular degeneration are: age over 55, smoking, family history, malnutrition, cardiovascular disease. Macular pigments play a major role in protecting the macula and provide conditions for the normal physiological activity of cells in this important area. Therefore, the destruction of the layer of macular pigments could lead to the creation of conditions for the development of macular degeneration. The daily requirements for macular carotenoids are 3-6 mg / day (Public Health England 2018). The average daily dietary intake of lutein and zeaxanthin in developed countries is only 1-3 mg / day. (Connelly 2011, Abdel-Aal 2013). This fact, along with other risk factors, is the basis for the rising incidence of macular degeneration. Therefore, it is necessary to introduce macular pigments with food supplements in a ratio of lutein / meso-zeaxanthin / zeaxanthin -10/10/2, which shows the highest efficiency in improving the condition of the macular pigment and the quality of vision.
The carotenoids lutein, zeaxanthin and meso-zeaxanthin are distributed in a very specific way in the macula. The periphery of the macula contains lutein as the dominant carotenoid. While meso-zeaxanthin is dominant in the center of the macula and between these two areas - the center and the periphery, the dominant carotenoid is zeaxanthin. That is why the presence of all three carotenoids is very important. Meso-zeaxanthin is particularly important because on the one hand it is concentrated in the central part of the macula, where there is a large amount of specific light-sensitive cells called "cones", and on the other hand it is almost absent in the daily diet.
Macular pigments absorb shortwave blue light. Light causes phototoxic damage to the macula. Macular pigments are pre-receptor located. Their main role is to filter the shortwave light spectrum with a length of about 460 nm, falling on the receptors. Irradiation of photoreceptors with short-wavelength light increases the production of free radicals that destroy the macula. Smoking cigarettes, inhaling smoke, ionizing radiation, light of a certain wavelength, cause photolysis of oxygen and increase the amount of free radicals. Macular pigments are very powerful antioxidants against free radicals [Li, 2010]. Maximum antioxidant potential is achieved when all three macular pigments are taken in a certain ratio: Lutein / Meso-zeaxanthin / Zeaxanthin-10/10/2.
EFFICACY DATA:
EFFICACY DATA:
There are a large number of publications and studies that prove that the triple combination of carotenoid pigments-Lutein / Meso-zeaxanthin / Zeaxanthin in a ratio of 10/10/2 have the highest effect on improving vision.
A study demonstrating an increase in serum concentrations of Meso-zeaxanthin and Lutein after supplementation with the three macular carotenoids (in the ratio Meso-zeaxanthin / Lutein / Zeaxanthin in [mg]) (10: 10: 2) resulted in a significant increase in the concentration of macular pigments in serum after two weeks [1].
Patients taking a triple combination of macular carotenoids (in the ratio MZ: L: Z [mg] 10: 10: 2) showed a significant increase in serum concentrations of these carotenoids and a subsequent increase in pigment in the macula. [2]
The formulation containing the triple combination of macular carotenoids (in the ratio MZ: L: Z [mg] 10: 10: 2) was most effective in achieving the highest combined concentration of the three macular pigments in the serum, thus potentially optimizes the bioavailability of these compounds [3].
The triple combination of macular carotenoids, which also contains meso-zeaxanthin, leads to a greater increase in pigment in the macula compared to the absence of meso-zeaxanthin in the intake [4].
The triple combination of macular carotenoids potentially offers advantages over meso-zeaxanthin-free preparations, both in terms of increasing pigment in the macula and in terms of improving vision in persons suffering from retinal diseases [5].
One study demonstrated that the inclusion of meso-zeaxanthin in the formulation of the supplement provides benefits in terms of increased macular pigment and in terms of increased contrast sensitivity in individuals with early diagnosed macular pigment damage [6].
In individuals without retinal disease, supplementation with a formula containing the triple combination of macular carotenoids leads to measurable improvements in visual efficiency [7].
A recent study by researchers at Moorfields Eye Hospital in London, UK, showed that a composition containing a triple combination of macular carotenoids in the ratio Meso-zeaxanthin: Lutein: Zeaxanthin - 10: 10: 2 improves many aspects of visual efficiency in various diseases of the retina [8].
Meta-analysis: a publication from China shows that the triple combination of meso-zeaxanthin, lutein and zeaxanthin improves vision qualitatively in both patients with age-related macular pigment impairment and in individuals without macular pigment impairment [9].
REFERENCES:
1.2010 – Connolly et al
2.2011 – Connolly et al
3.2012 – Meagher et al
4.2014 – Thurnham et al
5.2012 – Loughman et al
6.Supplementation with tree differtent macular carotenoid formulations wth patients with early age-related macula degeneration. Sarah Sabour-Pickett, Phd, Stephen Beatty, Md, Frcophth, Eithne Connolly, Bsc, James Loughman, Phd, Jim Stack, Phd, †Alan Howard, Phd, Ronald Klein, Md, Mph, Barbara E. Klein, Md, Mph, Stacy M. Meuer, Bsc, Chelsea E. Myers, Mstat, Kwadwo O. Akuffo, Od, John M. Nolan, Phd
7.Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1. Nolan JM1, Power R1, Stringham J2, Dennison J1, Stack J1, Kelly D1, Moran R1, Akuffo KO1, Corcoran L1, Beatty S1. 2016 Jun 1;57(7):3429-39. doi: 10.1167/iovs.16-19520.
Macular Pigment Research Group Nutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology, West Campus, Carriganore, Waterford, Ireland
Nutritional Neuroscience Laboratory, Department of Physiology and Pharmacology, University of Georgia, Athens, Georgia, United States
8.An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases. Roxanne Crosby-Nwaobi, Philip Hykin, Tunde Peto, and Sobha Sivaprasa. Clinical Ophthalmology, 2016 May 11
9.Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients. 2016 Jul 12;8(7). Ma L1,2, Liu R3,4, Du JH5, Liu T6, Wu SS7, Liu XH8. 1
DOSAGE AND METHOD OF ADMINISTRATION:
Take 1 time a day with water during meals.
CONTRAINDICATIONS:
Do not take if you are allergic to any of the ingredients.
SPECIAL WARNINGS:
In case of pregnancy and lactation, consult your doctor.
Do not exceed the recommended daily dose.
Do not use as a substitute for a varied and rational diet.
Do not use if package is damaged or missing.
INSTRUCTIONS FOR USE:
No special instructions.
UNWANTED REACTIONS:
No side effects have been identified.
EXPIRY DATE AND STORAGE CONDITIONS:
Store in a cool, dry place at a temperature below 25 ° C.
Use before: see the date marked on the package.
Keep out of reach of children under three years.
PACKAGE:
Macshield is available in a carton containing 30 soft gelatin capsules, two blisters of 15 capsules.
Batch number: see package.
Net amount: 18.9g E.
PRODUCER:
Alliance Pharmaceuticals Ltd
Avobridge House, Bath Road, Chippenham.Wiltshire. SN152BB. UK
OFFICIAL PARTNER FOR BULGARIA:
AVENDRA PHARMA Ltd.
Bulgaria 7000, Ruse , Pleven str, 3
Phone: +359888575008
www.avendrapharma.com
info@avendrapharma.com
